Once again fate throws Sam Fisher to the places where no one can get, and makes him do things that nobody can! A terrible catastrophe threatens the whole world: to avoid retribution an Indonesian leader Zuhadi Sadono developed a cunning plan, which provided him with full security. Every day he was supposed to get in touch with his people, and if they do not receive any news from their leader they immediately ran the mechanism of biological activation of the vast number of bombs, which spread the smallpox virus in all the big cities of the world!