PhoneTweak - BerryTweak lets you tweak your BlackBerry how you want it, including automatically locking the screen and keyboard during calls. BerryTweak is fully configurable and lets you set options for Phone, Messages, Power, Connections, Clock and LED. There is even a handy flashlight feature.
Automatically lock screen/keyboard during calls
AutoEarpiece - This application is very simple:
You can select the checkbox in the application to auto-answer a call when a headset is connected. Perfect when you ride a bike and cannot click on the answer-button